We study the workings of the brain
What are the molecular mechanisms that underlie learning, memory and behavior?
Learning and memory involve plastic changes in neural circuits. These changes occur mostly at synapses – specialized points of contact between neurons. The Maricq lab is working towards a mechanistic understanding of synaptic development, function and plasticity.
To learn more about how synapses work, we study the development and function of neural circuits in the nematode Caenorhabditis elegans. Our strategy begins with genetics.
How do neural circuits control behavior?
We use genetics, cell biology, and electrophysiology to study how ionotropic glutamate receptors (iGluRs) modify the activity of neural circuits that regulate defined behaviors.
How are synaptic proteins delivered to and removed from synapses?
We use streaming confocal microscopy to study the motor-mediated transport of iGluRs. This provides insight into molecular mechanisms that contribute to the control of synaptic strength.
What genes are required for signaling at glutamatergic synapses?
We use forward genetic screens to identify proteins required for the regulation and function of iGluRs.